http://13.232.72.61:8080/jspui/handle/123456789/187 Sat, 04 Apr 2026 02:58:41 GMT 2026-04-04T02:58:41Z http://13.232.72.61:8080/jspui/handle/123456789/6663 Title: Formulation And Evaluation of Nano Drug Delivery System of Antibiotic Drug Using Factorial Design Authors: Pavan Kumar, P Naga; Goli, Divakar Abstract: The aim of this study was to develop the nanosuspension of clarithromycin for enhancing the solubility and in vitro drug release property of drug. In the present study the area of interest are drugs belonging to class II of BCS classification. Nanosuspension is a submicron colloidal dispersion of drug particles which are stabilized by surfactants ranging between 200-600nm, and is considered as a viable drug delivery strategy to develop the poorly soluble drugs. The drug nanosuspension was prepared by precipitation-sonication method using 23 factorial design to conduct the experiments. PEG-200 as polymer, Poloxamer-188 as co-polymer and stabilizer, two different solvents - acetone and water were used in the process. FTIR analysis and thermal analysis proved compatibility between drug and polymers. Characterization parameters such as the FTIR analysis, TG-DT analysis, particle size analysis, AFM analysis, poly dispersity indexanalysis, solubility studies, entrapment efficiency, drug content estimation, in vitro drug release studies, zeta potential analysis were carried out. All formulations were in the size range of 200-900nm where as the best formulation (F4) was around 218nm. Marked improvement in solubility and drug release studies were observed when compared to that of pure drug (of size ranging up to 5μm). Zeta potential and poly dispersity index determined the stability of the best formulation (F4). Short term stability studies carried out for the best formulation (F4) showed that nanosuspension formulation of clarithromycin will remain stable at 4°C compared to room temperature. Based on the R2 and N values, it was concluded that the best formulation (F4) follows zero order drug release and mechanism of drug release was anomalous (diffusion coupled with erosion). Finally it can be stated that formulating poorly water soluble drugs of BCS class II in the form of nanosuspension would be a promising approach in delivery by oral route. Description: Dissertation Tue, 01 May 2012 00:00:00 GMT http://13.232.72.61:8080/jspui/handle/123456789/6663 2012-05-01T00:00:00Z http://13.232.72.61:8080/jspui/handle/123456789/6662 Title: Design And In Vitro Evaluation of a Novel Sustained Release Double layered Tablets of Lornoxicam Authors: Krishna, Muppa Rama; Kalyanappa, Shivanand Abstract: The objective of the present study was to develop double layered tablets (DLTs) of lornoxicam, a highly potent non steroidal anti-inflammatory drug. DLTs is comprising of fast release layer and a sustained release layer, anticipating the rapid drug release that starts in the stomach rapidly lleviate the symptoms and continous in the intestine to maintain the prolonged analgesic effect. DLT’s are characterized by initial drug release in the stomach and comply the requirements of sustained release portion of the dosage form. An inclusion complex of lornoxicam with β-cyclodextrin at 1:2 (drug:β-CD) molar ratio, was incorporated in the fast release layer to increase the release rate of lornoxicam in the stomach to produce rapid analgesic effect. Hydroxy propyl methyl cellulose (HPMC), a hydrophilic matrix forming agent, was integrated in the sustained release layer to provide the sustainment of drug release, F2 was selected as the best formulation as it fulfilled all the criteria. The drug release of F2 extended up to 12 h period. Based on the statistical analysis the drug release follows Anomalous diffusion mechanism. Two months of stability study were carried out at 30 ± 2°C / 65 ± 5 % RH and 40 ± 2°C / 75 ± 5 % RH for the best selected formulation. The results showed that there were no significant changes in all the parameters evaluated for the best formulation. Description: Dissertation Tue, 01 May 2012 00:00:00 GMT http://13.232.72.61:8080/jspui/handle/123456789/6662 2012-05-01T00:00:00Z http://13.232.72.61:8080/jspui/handle/123456789/6661 Title: Formulation and evaluation of nano drug delivery system of anti- inflammatory drug ibuprofen using factorial design Authors: Rani, Varsha; Goli, Divakar Abstract: The objective of the present work is an attempt to develop the nanosuspension of the hydrophobic anti- inflammatory drug Ibuprofen, using nonbiodegradable polymer and stabilizer in order to enhance its solubility by applying nanonization. Plan of research work 1. Characterization of drug by FTIR and DSC 2. Identification and confirmation for purity of drug 3. Preformulation studies of drug 4. Preparation of standard calibration curve of drug 5. Experimental designing for preparation of Nano-drug delivery system 6. Evaluation parameters . Solubility studies  Drug particle size analysis by particle size analyzer or SEM  Invitro dissolution studies  Statistical pharmacokinetic analysis of invitro data. 7. Stability studies of nanoparticles as per ICH guidelines Description: Dissertation Tue, 01 May 2012 00:00:00 GMT http://13.232.72.61:8080/jspui/handle/123456789/6661 2012-05-01T00:00:00Z http://13.232.72.61:8080/jspui/handle/123456789/6660 Title: Formulation and Evaluation of microspheres containing antiasthmatic drug Authors: Riddhi D, Patel; Kalyanappa, Shivanand Abstract: Purpose: The aim of this study was to formulate and evaluate microspheres of Salbutamol Sulphate, using Eudragit S100 and Eudragit L100 polymers in different ratios as release retardant material. Microspheres were prepared by solvent evaporation method using ethanol/liquid paraffin system. The prepared microspheres were characterized for the particle size, drug loading, angle of repose, Fourier transform infrared spectroscopy, Differential scanning calorimetry and Scanning electron microscopy. The prepared microspheres were white, free flowing and spherical in shape. The drug loaded microspheres showed 84.21-94.62 % of drug entrapment and release extended up to 12 h. The FTIR spectra and DSC confirmed absence of drug polymer interactions. Scanning electron microscopy study revealed that the microspheres have rough surface and spherical in shape. The in vitro release studies showed prolonged release of the drug from the microspheres and the best fit with the highest correlation coefficient was observed in zero order plot than Higuchi and first order and the stability study confirmed that the formulation prepared were stable. Description: Dissertation Tue, 01 May 2012 00:00:00 GMT http://13.232.72.61:8080/jspui/handle/123456789/6660 2012-05-01T00:00:00Z