http://13.232.72.61:8080/jspui/handle/123456789/809 Sat, 04 Apr 2026 04:21:02 GMT 2026-04-04T04:21:02Z http://13.232.72.61:8080/jspui/handle/123456789/6657 Title: Formulation and evaluation of controlled release drug delivery system of an anti-asthmatic drug Authors: Reddy, Gujjula Lohith; S B, Sateesha Abstract: The objective of the present work is to formulate controlled release drug delivery system (two tablets packed in capsule of “0” size) of terbutaline sulphate, which has variable bioavailabilty because of variable absorption in acidic and neutral pH. One of the tablet releases the drug in the stomach by neutralizing the acidic pH of the stomach and the other releases the drug only in the small intestine for the remaining period of time. Three formulations of immediate release tablets of terbutaline sulphate were prepared by wet granulation technique using polymers Eudragit L100, HPMC K4M and calcium carbonate as a buffering agent. Seven formulations of sustained release tablets were prepared by direct compression method using the polymers Eudragit RS100, Eudragit RL100 and HPMC K4M. The formulated immediate release tablets and sustained release tablets were subjected for thickness, hardness, friability, weight variation, tensile strength, drug content, and in vitro release data. In addition, the immediate release tablets were also checked for their buffering capacity and disintegration time. Analysis of the drug release profile infers that drug release from the tablets was strongly dependent on the ratio and type of the polymers used in the formulations. Fitting of drug release data into kinetic models indicated zero order kinetics and the mechanism of drug release is found to be anomalous diffusion. Satisfactory formulation was checked for stability at 30±2°C/65±5% RH and at 40±2°C/75±5% RH for two months and showed no significant change in hardness, drug content and in vitro release profile. Description: Dissertation Tue, 01 May 2012 00:00:00 GMT http://13.232.72.61:8080/jspui/handle/123456789/6657 2012-05-01T00:00:00Z http://13.232.72.61:8080/jspui/handle/123456789/6656 Title: Formulation and in vitro evaluation of sustained release tablets of Ambroxol Hydrochloride Authors: N B, Poornima; Roy, Anup Kumar Abstract: Ambroxol hydrochloride has relatively short plasma half life. The need for the administration of the drug for two to three times a day can decrease patient compliance. Sustained release formulations that would maintain plasma level for 8-12 h might be sufficient for daily dosing of Ambroxol Hydrochloride. The overall objective of the present work was to develop an oral sustained release Ambroxol Hydrochloride tablet prepared by direct compression method using hydrophilic Eudragit RSPO and RLPO alone or in combination with hydrophobic ethylcellulose polymer as rate controlling factor. All the batches were evaluated for thickness, weight variation, hardness, friability and drug content and in vitro drug release for 12 h. The in vitro drug release study revealed that when Eudragit RSPO, RLPO and Ethylcellulose were used alone as the only retarding polymer, a sustained drug release pattern was not observed while, combining Eudragit with ethylcellulose, the drug release pattern was observed in a sustained manner for 12 h. F7 formulation sustained the drug release for longer period of time as compared to other formulations. So F7 was selected as the best formulation. Kinetic modeling of in vitro dissolution profiles revealed that the drug release mechanism ranges from diffusion controlled to anomalous type. Fitting the data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release. Description: Dissertation Tue, 01 May 2012 00:00:00 GMT http://13.232.72.61:8080/jspui/handle/123456789/6656 2012-05-01T00:00:00Z http://13.232.72.61:8080/jspui/handle/123456789/6655 Title: Development of Oral Enteric Controlled Release Formulation of Dexlansoprazole Using Mucoadhesive Agent Authors: Bhumkar, Sujeet S.; S B, Sateesha Abstract: The objective of this research work is to develop an oral enteric controlled dexlansoprazole (proton pump inhibitor) loaded sodium alginate beads for intestinal delivery. The influence of type and concentration of polymers on retarding the drug release in the stomach was tested for pH dependent polymers such as Eudragit L100 or cellulose acetate phthalate and time dependent polymers such as Eudragit RL100 and Eudragit RS100 by homogenizing with sodium alginate solution. The effects of factors like curing time, polymer and concentration of calcium chloride on drug entrapment efficiency and drug release were studied. Mucoadhesive studies, swelling index and scanning electron microscopy to understand surface morphology of the beads was also performed. The increase in concentration of calcium chloride results in smaller size of beads. The beads with longer curing time results with more rigid and stiff beads. The increase in polymer concentration results in increase in bead size. The efficiency of the polymer in retarding the drug release in gastric media is in the order of Cellulose acetate phthalate (2%w/v) > Eudragit RS100 (0.5%w/v)> Eudragit L100 (1.2%w/v)> Eudragit RL100 (0.5%w/v). The mucoadhesiveness observed for formulations made with pH dependent polymers is found to be 100% than made with time dependent polymers. CAP coated formulation showed diffusion patterned release kinetics and found to be stable at 30±2°C/65±5%RH for two months. Based on the above results Dexlansoprazole loaded sodium alginate beads coated with CAP is suitable to deliver the drug to small intestine more efficiently. Description: Dissertation Tue, 01 May 2012 00:00:00 GMT http://13.232.72.61:8080/jspui/handle/123456789/6655 2012-05-01T00:00:00Z http://13.232.72.61:8080/jspui/handle/123456789/6654 Title: Development of controlled release in situ gel for the treatment of periodontal diseases Authors: Anil Karthik, Malapaka; S B, Sateesha Abstract: In the present study an attempt was made to develop a controlled release in situ gel for the treatment of periodontal diseases. Periodontitis is an inflammatory condition that leads to destruction of periodontum, resorption of the alveolar bone and frequent tooth loss. In situ gel formulations (F0-F7) were developed for the treatment of periodontitis by temperature induced gelation technique. Thermoreversible Pluronic F127 was used as the main gelling agent, chitosan as the mucoadhesive agent and HPMC as the viscosifying agent. In the formulations HPMC 12-18 cps and HPMC 50 cps were used in various ratios in order to obtain the controlled drug release and other desired properties. Levofloxacin hemihydrate IP was used as the model drug. The formulations were analysed for pH, syringeability, gelation time and gelation temperature, rheological characteristics and in vitro drug release. All the developed formulations were syringeable through 21G needle. Gelation temperature was found to be 28°C. The gelation time of all the formulations ranged from few minutes to seconds. All the formulations exhibited thixotropic behaviour with pseudoplastic rheology. Viscosity of the formulations was found to have a direct influence on the drug release. An increase in the viscosity of the formulations, prolonged the drug release from 18 to 24h. The formulation F3 showed a maximum drug release in 24h following zero order kinetics with high regression co-efficient (r2=0.997) value. Stability study of the optimised formulation (F3) performed at 4-8°C for one month indicated no significant changes in the evaluated parameters. Description: Dissertation Tue, 01 May 2012 00:00:00 GMT http://13.232.72.61:8080/jspui/handle/123456789/6654 2012-05-01T00:00:00Z