Kinetics and Mechanistic Studies on Oxidation of Levocarnitine by Bromamine-T in HCl Medium Catalyzed by Ru(III)

Abstract

A kinetic study on RuCl3-catalysed oxidation of levocarnitine (LC) by sodium N-bromo-p-toluenesulphonamide or bromamine-T (BAT) has been carried out in HCl medium at 303 K. The reaction rate shows a 􀄕rst order dependence on [BAT]0 and fractional order with respect to both [LC]0 and [H+]. Addition of the reaction product, p-toluenesulphonamide, retards the rate. e addition of RuCl3 and chloride ions to the reaction mixture shows an increase in the rate of the reaction. e dielectric effect is positive. e variation of ionic strength of the medium has no signi􀄕cant effect on the rate of the reaction. e reaction fails to initiate polymerization of acrylamide. Michaelis-Menten type of kinetics has been proposed. ermodynamic parameters have been computed from Arrhenius plot by studying the reaction at different temperatures.The reaction stoichiometry and oxidation products were identi􀄕ed. Based on the experimental observations a suitable mechanism was proposed and rate law deduced.