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DC Field | Value | Language |
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dc.contributor.author | Kumar Patel, Devendra | - |
dc.contributor.author | Giles, D | - |
dc.date.accessioned | 2023-01-27T10:42:03Z | - |
dc.date.available | 2023-01-27T10:42:03Z | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | http://lrc.acharyainstitutes.in:8080/jspui/handle/123456789/6242 | en_US |
dc.identifier.uri | http://13.232.72.61:8080/jspui/handle/123456789/6321 | - |
dc.description | Dissertation | en_US |
dc.description.abstract | Various heterocyclic compounds possess wide range of biological and pharmacological activities. Among a wide variety of heterocycles that have been explored for developing pharmaceutically important molecules such as Chalcones and Pyrimidines have played an important role in the area of medicinal chemistry. A new series of chalcones were prepared by reacting acetylated 4-amino 1, 2, 4-triazoles and 2-amino 1, 3-thiazole by condensing with various substituted aromatic aldehydes in presence of 70% NaOH as a base. The resultant chalcones undergo cyclization with thiourea in presence of alcoholic KOH to yield pyrimidine derivatives. The structures of the final synthesized compounds were confirmed by IR, MASS & 1H NMR spectra. The newly synthesized compounds were screened for their antimicrobial and antifungal activities. Some of the synthesized compounds showed very good antimicrobial and moderate antifungal activities. | en_US |
dc.language.iso | en | en_US |
dc.subject | Substituted chalcones, Pyrimidine derivatives, Antibacterial activity, Antifungal activity. | en_US |
dc.title | Synthesis and Biological Activity of Substituted Chalcone Derivatives | en_US |
dc.type | Thesis | en_US |
Appears in Collections: | Dissertations |
Files in This Item:
File | Description | Size | Format | |
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D K ABSTRACT.pdf | 57.94 kB | Adobe PDF | View/Open |
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