Please use this identifier to cite or link to this item: http://13.232.72.61:8080/jspui/handle/123456789/6323
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dc.contributor.authorLohitha, Putha;Giles,D-
dc.date.accessioned2023-01-27T10:56:12Z-
dc.date.available2023-01-27T10:56:12Z-
dc.date.issued2009-05-
dc.identifier.citationhttp://lrc.acharyainstitutes.in:8080/jspui/handle/123456789/6242en_US
dc.identifier.urihttp://13.232.72.61:8080/jspui/handle/123456789/6323-
dc.descriptionDissertationen_US
dc.description.abstractIndoles and their derivatives find a prominent place in synthetic organic chemistry, as they are found to be potent pharmacophores. They have been reported to possess a wide variety of biological properties viz. anti-inflammatory, anti cancer, anti diabetic, anti malarial, anti fungal, anti bacterial and anti convulsant activities. Indole derivatives were synthesized by reacting substituted indoles with various types of amines in presence of formaldehyde and dimethyl formamide to form mannich bases. The newly synthesized compounds were characterized by physical constants and by spectral methods viz. FT-IR, 1H NMR & MASS spectra. The invivo anti-inflammatory activity and the analgesic activity of the compounds were evaluated by Carrageenan-induced paw edema model in rats by measuring the paw volume and Acetic-acid induced writhing in mice by measuring the number of writhings respectively. Some of the newly synthesized compounds showed good anti-inflammatory and analgesic activity.en_US
dc.language.isoenen_US
dc.publisherAcharya & BM Reddy College of Pharmacy (ABMRCP)en_US
dc.subjectIndole; invivo anti-inflammatory activity; analgesic activity.en_US
dc.titleStudies on Synthesis and Pharmacological Activity of Substituted Indole Derivativesen_US
dc.typeThesisen_US
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