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DC Field | Value | Language |
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dc.contributor.author | Shashidhar, B V | - |
dc.contributor.author | Swamy, P M,Gurubasavaraja | - |
dc.date.accessioned | 2023-02-15T06:14:37Z | - |
dc.date.available | 2023-02-15T06:14:37Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | Shashidhar, B V; Swamy, P M,Gurubasavaraja;: Mannich condensation, Dehydroacetic acid, Antimicrobial activity.;Synthesis and pharmacological activity of some mannich base derivatives;http://lrc.acharyainstitutes.in:8080/jspui/handle/123456789/6242 | en_US |
dc.identifier.uri | http://13.232.72.61:8080/jspui/handle/123456789/6577 | - |
dc.description | Dissertation | en_US |
dc.description.abstract | A series of Mannich bases of dehydroacetic acid (3-acetyl-4-hydroxy-6 -methyl-2H pyran-2-one) and substituted dehydroacetic acid 1a-4a, 1b-4b, 1c-4c, 1d-4d were synthesized by Mannich condensation method. All synthesized Mannich base compounds were characterized by IR, 1H NMR and Mass spectra. Synthesized compounds were screened for their antibacterial activity against gram positive organisms Bacillus subtilis, Staphylococcus aureus and gram negative organism Escherichia coli, Klebsiella pneumoniae by cup plate method at 50, 75, 100 µg/ml and compared with standard Ampicillin. Synthesized compounds were also screened antifungal activity against fungus Penicillium notatum, Aspergillus niger, Candida tropicalis and Candida albicans by cup plate method at 50, 75, 100 µg/ml and compared with standard Fluconazole. It is observed that the newly synthesized compounds showed significant activity whereas 1c and 1d showed no significant antibacterial activity and also 1c showed no significant antifungal activity | en_US |
dc.language.iso | en | en_US |
dc.publisher | Acharya & BM Reddy College of Pharmacy (ABMRCP) | en_US |
dc.subject | : Mannich condensation, Dehydroacetic acid, Antimicrobial activity. | en_US |
dc.title | Synthesis and pharmacological activity of some mannich base derivatives | en_US |
dc.type | Thesis | en_US |
Appears in Collections: | Dissertations |
Files in This Item:
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7 Abstract.pdf | Abstract | 9.21 kB | Adobe PDF | View/Open |
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